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volume of distribution
This term is a specialized pharmacokinetic concept used primarily in pharmacology and clinical medicine. It does not describe a physical, measurable space but rather a theoretical proportionality constant. A high value suggests the drug has left the bloodstream to enter tissues, while a low value indicates the drug remains largely confined to the plasma.
Because it is a technical parameter, it is almost exclusively used in professional medical or scientific contexts. It is typically treated as a singular conceptual entity in research papers and clinical reports, though it can be discussed in the plural when comparing different drugs or patient cohorts.
Ý nghĩa
A pharmacokinetic parameter that represents the theoretical volume that would be necessary to contain the total amount of an administered drug at the same concentration as it is found in the blood plasma.
The drug's high volume of distribution indicates that it has extensively distributed into the peripheral tissues rather than remaining in the plasma.